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Sunday, August 2, 2020 | History

2 edition of Molecular and cellular mechanisms of sulfur mustard-induced lesions of human skin found in the catalog.

Molecular and cellular mechanisms of sulfur mustard-induced lesions of human skin

Maria Anna Elisabeth Mol

Molecular and cellular mechanisms of sulfur mustard-induced lesions of human skin

by Maria Anna Elisabeth Mol

  • 226 Want to read
  • 34 Currently reading

Published by NKB Offset BV in Bleiswijk .
Written in English

    Subjects:
  • Mustard gas -- Toxicology.,
  • Dermatotoxicology.

  • Edition Notes

    Statementdoor Maria Anna Elisabeth Mol.
    Classifications
    LC ClassificationsRA1247.M8 M65 1992
    The Physical Object
    Pagination147 p. :
    Number of Pages147
    ID Numbers
    Open LibraryOL1454354M
    LC Control Number93108230

      Sulfur mustard (SM: 2,2′dichlorodiethyl sulfide) is an alkylating agent (Auerbach, ; Heston, ; Papirmeister et al., ) that has cytotoxic and vesicant properties (Gross et al., ; Papirmeister et al., b) and has been used as a chemical warfare this agent continues to pose a threat as a chemical weapon, tissue models used in skin biology Cited by:   Skin exposure to sulfur mustard (SM) provokes long-term complications in wound healing. Similar to chronic wounds, SM-induced skin lesions are associated with low levels of oxygen in the wound tissue. Normally, skin cells respond to hypoxia by stabilization of the transcription factor hypoxia-inducible factor 1 alpha (HIF-1α). HIF-1α modulates expression of Cited by: 4.

    Sulfur mustard (2,2-dichlorodiethyl sulfide, SM) is one of the vesicant classes of chemical warfare agents that causes blistering in the skin and mucous membranes, where it can have lingering long-term effects for up to ten years (1). SM was employed extensively by the Iraqi army against not only Iranian soldiers but also civilians between and , resulting in over , Cited by:   Molecular mechanism underlying pathogenesis of lewisite-induced cutaneous blistering and inflammation: Chemical chaperones as potential novel antidotes Time course of lewisite-induced skin lesions and inflammatory response in the SKH-1 hairless mouse model. Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and Cited by: 2.

    Development of a reactive topical skin protectant. J Appl Toxicol 19 Suppl 1: S47–S53, Google Scholar; 10 Calvet JH, d'Ortho MP, Jarreau PH, Levame M, Harf A, and Macquin-Mavier I. Glucocorticoids inhibits sulfur mustard-induced airway muscle hyperresponsiveness to substance P. J Appl Physiol –, Link | ISI Google ScholarCited by:   Sulfur mustard (SM), or mustard gas, is a bifunctional alkylating agent (bis[2-chloroethyl] sulfide) (see Fig. 1 for structure). It was first synthesized in the early 19th century by Despretz () and later by Guthrie () and Niemann (), during which time its distinctive mustard and garlic-like odor and blistering action on the skin were by:


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Molecular and cellular mechanisms of sulfur mustard-induced lesions of human skin by Maria Anna Elisabeth Mol Download PDF EPUB FB2

Sulfur mustard (SM) is a strong alkylating agent, which produces subepidermal blisters, erythema and inflammation after skin contact. Despite the well-described SM-induced gross and histopathological changes, the exact underlying molecular mechanisms of these events are still a matter of research.

Sulfur mustard (SM) is a strong alkylating agent, which produces subepidermal blisters, erythema and inflammation after skin contact. Despite the well-described SM-induced gross and histopathological changes, the exact underlying molecular mechanisms of these events are still a matter of by: Objective: Sulfur mustard (SM) is a potent alkylating agent that can induce severe cutaneous injury.

Though much is known regarding the gross pathology of SM injury, the molecular and cellular basis for this pathology is not well by: Objective: Sulfur mustard (SM) is a potent alkylating agent that can induce severe cu. taneous injury.

Though much is known regarding the gross pathology of SM injury, the. molecular and cellular basis for this pathology is not well understood. Effective medical treatment and preventive measures for chemical warfare agent sulfur mustard (HD)-caused incapacitating skin toxicity are lacking, owing to limited knowledge of its mechanism of action.

The proliferating basal epidermal cells are primary major sites of attack during HD-caused skin by: Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug Author links open overlay panel Laurie B.

Joseph a Gabriella M. Composto a Roberto M. Perez a Hong-Duck Kim b Robert P. Casillas c Ned D. Heindel d Sherri C. Young d Carl J. Lacey d Jaya Saxena d Christophe D. Guillon d Cited by: 6. Sulfur mustard (SM) is a potent alkylating agent that can induce severe cutaneous injury.

Though much is known regarding the gross pathology of SM injury, the molecular and cellular. Skin is the fi rst organ exposed to sulfur mustard (SM). The mechanism of SM-induced cutaneous injury has not been fully clarifi ed so far, which.

The chemical warfare agent sulfur mustard (SM) severely affects the regeneration capacity of skin. The underlying molecular and cellular mechanisms, however, are far from clear.

Review Mechanism and treatment of sulfur mustard-induced cutaneous injury Gu Tianyi, * [email protected] Medical Unit, Armed Forces, WuxiJiangshu Province, China Medical Unit, Armed Forces Wuxi Jiangshu Province, China * Tel: Abstract Skin is the first organ exposed to sulfur mustard (SM).

The mechanism of SM-induced cutaneous injury Cited by: 5. Molecular and cellular mechanisms of sulfur mustard-induced (). Pagina-navigatie: Main; Save publication. Save as MODS; Export to Mendeley; Save as EndNote; Export to RefWorks; Title: Molecular and cellular mechanisms of sulfur mustard-induced lesions of human skin: Author: Mol, M.A.E.

Degree grantor: TU Delft, Delft University of Cited by: 2. Effective medical treatment and preventive measures for chemical warfare agent sulfur mustard (HD)-caused incapacitating skin toxicity are lacking, because of limited knowledge of its mechanism of action.

The proliferating basal epidermal cells are primary major sites of attack during HD-caused skin injury. Therefore, employing mouse JB6 and human HaCaT Cited by: Sulfur mustard (2,2-dichlorodiethyl sulfide, HD) is a chemical warfare agent that is a threat to both troops and civilians.

The focus of HD research has been on intracellular adduct formation leading to apoptosis and/or necrosis in cutaneous by: Molecular and cellular mechanisms of sulfur mustard-induced lesions of human skinCited by: 2.

Modulation of sulfur mustard induced cell death in human epidermal keratinocytes using IL and TNF-alpha. Molecular basis for mustard-induced vesication. Fundam Appl Toxicol. ;5(6 pt 2):S– Molecular mechanism of the cytotoxic action of difunctional alkylating agents and of resistance to this : Albert L.

Ruff and James F. Dillman. Uri Wormser, Berta Brodsky, Elena Proscura, Julie F. Foley, Tinette Jones and Abraham Nyska, Involvement of tumor necrosis factor-α in sulfur mustard-induced skin lesion; effect of topical iodine, Archives of Toxicology, /s, 79, 11, (), ().Cited by: Introduction.

Sulfur mustard [bis (2-chloroethyl) sulfide, SM], a vesicant, poses a potential threat of being used as a chemical warfare and terrorist weapon (Saladi et al.,Sharma et al.,Smith et al.,Smith and Skelton, ).It is a bi-functional alkylating agent which causes severe skin injuries with delayed vesication, and has been used in World War I and II Cited by: Download PDF: Sorry, we are unable to provide the full text but you may find it at the following location(s): (external link); http://oai Author: M.A.E.

Mol. In agreement with this fact, an interesting study has shown that overexpression of IL following exposure to sulfur mustard can suppress the proinflammatory cytokines (IL-8 and IL-6) in human epidermal keratinocytes and lead to delayed cell death.

These findings are in agreement with our research results showing that TGF-β, like IL, can also have a distinct role in the modulation of skin inflammation Cited by: This book provides a comprehensive review and analysis of the acute toxic effects of sulfur mustard (mustard gas); the injuries that this compound produces in skin, eye, airway, and other tissues; and possibilities for the prevention of these injuries through pharmacological intervention.

The book takes a multidisciplinary approach and is intended for all biomedical researchers. Skin intoxication by bis(β-chloroethyl)sulfide (BCES; sulfur mustard) induces cutaneous lesions similar to thermal burns, characterized by slowness of skin healing.

We have developed an in vitro model of skin equivalent to investigate mechanisms involved in this delay. Direct intoxication of dermal equivalent produced dose- and time-dependent by: To study the mechanisms of SM-induced apoptosis and its prevention in vitro, we have established a convenient fluorometric apoptosis assay using monolayer human epidermal keratinocytes (HEK) adaptable for multiwell plates (.CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Objective: Sulfur mustard (SM) is a potent alkylating agent that can induce severe cutaneous injury.

Though much is known regarding the gross pathology of SM injury, the molecular and cellular basis for this pathology is not well understood. General cellular processes such as inflammation, DNA .